Fig. 7: Chiauranib induces AIF-dependent apoptosis and eliminates tumor growth of NKT lymphoma in vivo. | Cell Death & Disease

Fig. 7: Chiauranib induces AIF-dependent apoptosis and eliminates tumor growth of NKT lymphoma in vivo.

From: Inhibition of extranodal NK/T-cell lymphoma by Chiauranib through an AIF-dependent pathway and its synergy with L-asparaginase

Fig. 7

Female 4-week-old NOD/SCID mice were randomly divided into four groups, five mice per group. Each group was intraperitoneally implanted with SNK6 cells transduced with control shRNA or shAIF. Human recombinant IL-2 (42 U/g) was intraperitoneal injected every other day. Mice received Chiauranib or DMSO treatment (0.18 μmol/g, intraperitoneal injection, every other day) for 1 week after inoculation with NKTL cells. A Representative pictures of tumor tissues from four groups of mice. B Tumor weight (g) was measured 3 weeks after the inoculation of NKTL cells after implantation; n = 5 per group. C Protein extracts from mice tumor tissue were analyzed by immunoblotting for the AKT-GSK3B-VDAC pathway. D, E Tunnel assay of mice tumor tissue. Bar = 50 µm.

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