Fig. 6: The STAT3-TIM-3 axis augments the Th2 response in LD-infected mice. | Cell Death & Disease

Fig. 6: The STAT3-TIM-3 axis augments the Th2 response in LD-infected mice.

From: TIM-3 increases the abundance of type-2 dendritic cells during Leishmania donovani infection by enhancing IL-10 production via STAT3

Fig. 6

Control-silenced BMDCs or STAT3-silenced BMDCs (with or without TIM-3 overexpression) were adoptively transferred into LD-infected mice (see Fig. 5 legend for experimental details). On the 48th day postinfection, the splenocytes were prepared from these mice for various analyses indicated in panels (A–C). A, B The frequency of CD4+ (A) and CD8+ (B) T cells expressing IFNγ or IL-10 was evaluated by flow cytometry (representative data of n = 6). C Cumulative data of n = 6 mice per group are plotted in the graphs. Each symbol represents the data of an individual mouse, and the bars indicate means. **p < 0.01, ***p < 0.001; NS, not significant.

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