Fig. 3: Time-resolved proteomic analysis of liver exposed to CCl4.
From: Tolerance of repeated toxic injuries of murine livers is associated with steatosis and inflammation
a Volcano plots of differentially regulated proteins in weeks two, six, and ten. b The number of differentially regulated proteins is visualized via the bar charts. Time points are grouped into three phases characterizing the disease course of liver fibrosis. c Venn diagrams illustrate the unique and overlapping amount of proteins between the three phases. d Heatmap of uniquely deregulated proteins during phase III (n = 2–3 mice per time-point). e The longitudinal regulation of the proteins BIRC6, CYP2F2, FASN, and GLUL. f KiMONo models performed integration of proteomic, transcriptomic, blood, and tissue measurements.
