Fig. 1: Hepatic I/R injury induces the upregulation of KLF6.
From: KLF6 alleviates hepatic ischemia-reperfusion injury by inhibiting autophagy
a, b Heatmap and volcano plot for differentially expressed genes identified in GSE113024, GSE117066 and our RNA-Seq dataset. c Venn diagram of the number of co- and differentially expressed genes among the three datasets. d Liver tissues were immunohistochemically stained for KLF6 after ischemia/reperfusion (n = 5 per group). Scale bar, 50 μm. e, f KLF6 mRNA and protein levels were detected with RT-qPCR and western blotting analysis after I/R (ischemia 1 h and reperfusion 6 h) (n = 5 per group) or H/R (hypoxia 6 h and reoxygenation 2 h). Mean values ± SD are shown, and statistical significance was determined by two-tailed Student’s t test. *p < 0.05.
