Fig. 5: Zinc supplementation alleviates the psoriasis-like phenotype.
From: SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis
A Quantitative analysis of epidermal zinc ion levels in healthy skin and psoriatic lesions. The epidermal zinc ion concentration in healthy skin (n = 9) and psoriatic lesions (n = 9) was detected by flow cytometry. B Quantitative analysis of epidermal zinc ion concentrations after TPEN and/or zinc pyrithione (ZPT) treatment. Wild-type (WT) mice (n = 3) were administered ZPT after being treated with IMQ for 12 h every day, while Slc35e1-knockout (KO) mice (n = 3) were treated with TPEN after being treated with IMQ for 12 h every day. ZPT was administered as a zinc ion supplement. TPEN, an intracellular membrane-permeable ion chelator, was used to lower zinc ion concentrations. The epidermal zinc ion concentration in each group (n = 3) was detected by flow cytometry. C The Psoriasis Area and Severity Index (PASI) score for WT + IMQ (n = 4), KO + IMQ (n = 4), WT + IMQ + ZPT (n = 4), and KO + IMQ + TPEN (n = 4) mice. D H&E staining. E The mRNA level of psoriasis-related inflammatory factors. Data are presented as means ± SEM; *P < 0.05, **P < 0.01, ***P < 0.001.
