Fig. 7: Working model. | Cell Death & Disease

Fig. 7: Working model.

From: Downregulation of N6-methyladenosine-modified LINC00641 promotes EMT, but provides a ferroptotic vulnerability in lung cancer

Fig. 7

LINC00641 is modified by m6A and its stability is maintained by nuclear m6A reader YTHDC1. Knockdown of LINC00641 induces the accumulation of HuR in cytoplasm, which promotes N-cadherin by increasing the stability of CDH2 mRNA to initiate EMT. In another aspect, knockdown of LINC00641 boosts the susceptibility to ferroptosis inducers in lung cancer cells.

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