Fig. 7: Gal3 inhibition alleviated retinal angiogenesis. | Cell Death & Disease

Fig. 7: Gal3 inhibition alleviated retinal angiogenesis.

From: Microglial Galectin3 enhances endothelial metabolism and promotes pathological angiogenesis via Notch inhibition by competitively binding to Jag1

Fig. 7

A CX3CR1-GFP mice were subjected to intravitreous injection of PBS, and anti-Gal3 with 25 and 100 ng/μl on P12 when the OIR model was constructed. B IF staining of retinal vessels (CD31, red) and microglia (CX3CR1, GFP) on P17 in the flat-mounted and cross-section from the blank, PBS, and anti-Gal3(25 and 100 ng/μl) group. (n = 3 per group). Scale bar, 200 µm. C Schematic illustration of the mechanism by which microglia-derived Gal3 promoted retinal angiogenesis. Bars = means ± SD; *P < 0.05; **P < 0.01, NS no significance.

Back to article page