Fig. 3: Low CELF6 expression in CRC and LINC01594 promote CRC metastasis by inhibiting CELF6. | Cell Death & Disease

Fig. 3: Low CELF6 expression in CRC and LINC01594 promote CRC metastasis by inhibiting CELF6.

From: Long noncoding RNA LINC01594 inhibits the CELF6-mediated splicing of oncogenic CD44 variants to promote colorectal cancer metastasis

Fig. 3

A The GEPIA online database showed that CELF6 was expressed at low levels in CRC (p < 0.05), and statistical data are shown. B qRT‒PCR was used to determine the expression of CELF6 in CRC. ***p < 0.001. C IF confirmed that CELF6 is located in the nucleus. D IHC was used to determine CELF6 expression in 4 pairs of adjacent tissues and CRC tissues. E Effect of CELF6 overexpression and knockdown on CRC cell migration and invasion. (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001. F Effect of CELF6 re-expression and re-knockdown on the migration and invasion of SW480 and LoVo cells with LINC01594 overexpression and knockdown. (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001. G Wound-healing assays of the effects of CELF6 re-expression and re-knockdown on the migration of SW480 and LoVo cells with LINC01594 overexpression and knockdown. (n = 3). *p < 0.05, **p < 0.01, ***p < 0.001.

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