Fig. 1: BCKDK is upregulated in BRCA and associated with poor prognosis in BRCA patients. | Cell Death & Disease

Fig. 1: BCKDK is upregulated in BRCA and associated with poor prognosis in BRCA patients.

From: BCKDK regulates breast cancer cell adhesion and tumor metastasis by inhibiting TRIM21 ubiquitinate talin1

Fig. 1

A The mRNA expression of BCKDK in normal and tumor tissues in the TCGA database; the analysis was performed by the R project. Error bars represent the mean ± SD values. B The paired differential gene expression between normal and BRCA tumor tissue. C The predictive power of BCKDK to predict tumor and normal outcomes. The closer to 1 the AUC value, the better the predictive power (AUC = 0.811, CI = 0.782–0.839). D Immunohistochemical analysis of BCKDK expression in breast cancer tumors. Representative BCKDK immunohistochemical staining images in serial sections from the same tumor tissue samples and axillary lymph node metastases tissue, scale bar 100 μm. E BCKDK expression in the indicated four breast cancer cell lines was analyzed by western blot.

Back to article page