Fig. 3: Interleukin (IL)-10 is primarily secreted by B cells during acute lung injury (ALI) resolution.
From: B cell-derived IL-10 promotes the resolution of lipopolysaccharide-induced acute lung injury
A Flow cytometry of GFP(IL-10)+ B cells in the lungs. B Proportion and number of GFP(IL-10)+ B cells as a proportion of live events. The lung total number of cells was then multiplied by the ratio to give the total GFP(IL-10)+ B cells count. (n = 8). C The number of different GFP (IL-10)-secreting cell subsets in the lungs (n = 9–10); DC dendritic cells, MF macrophages, MO monocytes, EC epithelial cells. D The proportion of IL-10-secreting subpopulations in the lungs of IL-10-GFP mice during LPS exposure (n = 9–10). E Immunofluorescence in the lungs of mice after four days of LPS exposure and the proportion of IL-10-secreting B cells (n = 3). Scale bars, 20 μm. Representative one of two independent experiments. Student’s t-test was used for the statistical analyses.
