Fig. 2: The mechanisms of TIGIT co-inhibition. | Cell Death & Disease

Fig. 2: The mechanisms of TIGIT co-inhibition.

From: TIGIT, a novel immune checkpoint therapy for melanoma

Fig. 2

TIGIT exerts inhibitory effects on innate and adaptive immunity through multiple mechanisms. 1. TIGIT binds CD155 to trigger T/NK cell-intrinsic inhibition; 2. TIGIT binds CD155 to induce immunosuppressive DCs; 3. TIGIT binds CD155 to inhibit CD226 signaling; 4. TIGIT binds CD155 to enhance immunosuppression of Tregs; 5. Fap2 protein from Fusobacterium nucleatum binds TIGIT to induce T/NK cell inhibition.

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