Fig. 9: ApoExos transfer functional mRNAs to endothelial cells via phosphatidylserine-dependent macropinocytosis. | Cell Death & Disease

Fig. 9: ApoExos transfer functional mRNAs to endothelial cells via phosphatidylserine-dependent macropinocytosis.

From: Apoptotic exosome-like vesicles transfer specific and functional mRNAs to endothelial cells by phosphatidylserine-dependent macropinocytosis

Fig. 9

ApoExo uptake depends on phosphatidylserine-dependent macropinocytosis, which is further enhanced by ApoExos, which induce an increase the macropinocytic activity in endothelial cells. Once internalized, PCSK5 mRNA, the most abundant mRNA in ApoExos, escapes lysosomal degradation to increase PCSK5 protein expression in endothelial cells. The schematic was created with BioRender.com.

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