Fig. 7: Exosome PGAM1 promotes PCa angiogenesis and metastasis in vivo.
From: Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1
A, B subcutaneous tumor specimen maps. C Tumor growth curves were plotted for nude mouse xenografts treated with different groups of exosomes (DU145-NC-PGAM1-EXO, DU145-SH1-PGAM1-EXO and DU145-SH2-PGAM1-EXO) given. D The dissected subcutaneous tumor xenografts were weighed and analyzed by One-way analysis of variance (ANOVA). E Schematic diagram of caudal vein injection in nude mice with different groups of exosomes. F–H The luciferase activity (radiance values) of lung metastases at 6 weeks was measured by an in vivo imaging system. I Representative images of H&E staining of lung metastatic tumor sections from nude mice. J Representative images of PGAM1 and CD31 from IHC stained nude mice with metastatic lung tumors. The scale bar in 100× images represents 100 µm. The scale bar in 200× images represents 50 µm. (Error bars represent means ± SD; *P < 0.05, **P < 0.01, ***P < 0.001).
