Fig. 5: PRGs were primarily expressed in immune cells.

A Feature plots depicting the expression of key pyroptosis, violin plots were also displayed to determine the cell type. B Representative IHC stanning of GZMA⁺, GSMDB⁺, CHMP4A⁺, NLRP1⁺, and IL18⁺ in melanoma specimens, especially in lymphocyte areas. Scale bar = 100 μm, n = 4 samples per group. C The quantification of PRGs protein in dermal areas, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, compared with the control group.