Fig. 6: RC48 sensitized anti-PD-1 therapy via activating the cGAS-STING pathway and promoting immune cell infiltration. | Cell Death & Disease

Fig. 6: RC48 sensitized anti-PD-1 therapy via activating the cGAS-STING pathway and promoting immune cell infiltration.

From: A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway

Fig. 6

A Immunofluorescence staining for p-TBK1 and p-IRF3 in tumor tissue in C57BL/6. B, C Immunohistochemical detection of IFN-β secretion in tumor tissue in BALB/c and C57BL/6. D LDH release assay was performed using Tils achieved from the syngeneic model of CT26HER2 as described in material and methods. E, F Examination of CD3+, CD8+, IFN-γ secretion in the tumor by flow cytometry in BALB/c and C57BL/6. *P < 0.05, **P < 0.01 versus as indicated. n.s. not significant. Scale bar, 100 μm.

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