Table 2 Univariate and multivariate analyses of OGDHL mRNA level and patient overall survival or disease-free survival.

From: The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling

Variable

Overall survival

Disease-free survival

Univariate analysis

Multivariate analysisc

Univariate analysis

Multivariate analysisc

 

HRa (95% CIb)

P value

HRa (95% CIb)

P value

HRa (95% CIb)

P value

HRa (95% CIb)

P value

Age (≤60 years vs. >60 years)

1.778 (1.310–2.414)

<0.001*

1.614 (1.186–2.197)

0.002*

1.433 (0.913–2.248)

0.117

Gender (female vs. male)

1.055 (0.775–1.435)

0.735

1.199 (0.7351–1.956)

0.463

T stage (T1 or T2 vs. T3 or T4)

3.154 (2.331–4.267)

<0.001*

6.766 (4.089–11.195)

<0.001*

N stage (N0 or NX vs. N1)

3.852 (2.086–7.115)

<0.001*

2.334 (1.246–4.370)

0.008*

6.989 (3.323–14.696)

<0.001*

2.918 (1.377–6.187)

0.005*

M stage (M0 or MX vs. M1)

4.376 (3.213–5.958)

<0.001*

12.237 (7.753–19.315)

<0.001*

4.661 (2.801–7.756)

<0.001*

G grade (G1 or G2 vs. G3 or G4)

2.564 (1.826–3.600)

<0.001*

1.753 (1.229–2.498)

0.002*

5.373 (2.957–9.763)

<0.001*

2.991 (1.617–5.532)

<0.001*

TNM stage (Stage I + II vs. Stage III + IV)

3.840 (2.800–5.265)

<0.001*

2.959 (2.116–4.140)

<0.001*

11.429 (6.285–20.786)

<0.001*

4.281 (2.159–8.488)

<0.001*

  1. aHazard ratio, estimated from Cox proportional hazard regression model.
  2. bConfidence interval of the estimated HR.
  3. cMultivariate models were adjusted for T, N, M classification, age, and gender.
  4. “*” indicates that the p-value is statistically significant, p < 0.05.
  5. Relevant clinical data of ccRCC patients are all from the TCGA-KIRC database.