Fig. 6: Lenvatinib modulates the expression of AZGP1 by regulating H3K27Ac. | Cell Death & Disease

Fig. 6: Lenvatinib modulates the expression of AZGP1 by regulating H3K27Ac.

From: AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway

Fig. 6

A, B The protein expression levels of H3K27Ac and HDAC1 were detected in OZ and RBE cells after lenvatinib treatment by Western blotting. C, D The protein expression levels of H3K27Ac and HDAC1 in the PDX model after lenvatinib treatment. E AZGP1 and H3K27Ac expression was detected in OZ and RBE cells after lenvatinib treatment using immunofluorescence. F, G The expression level of H3K27Ac in the AZGP1 promoter region of OZ and RBE cells treated with lenvatinib was detected by ChIP. ns, nonsignificant. *p < 0.05, and **p < 0.01.

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