Fig. 2: Knockdown Sorcin inhibited HCC cell proliferation, migration, and invasion. | Cell Death & Disease

Fig. 2: Knockdown Sorcin inhibited HCC cell proliferation, migration, and invasion.

From: Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma

Fig. 2

A Sorcin expression was higher in HCC-LM3/Huh-7 cells than in immortalized normal liver cells L02 by western blot. B, C Knockdown and overexpression of Sorcin were achieved in HCC-LM3 and HuH7 cells. D, E The CCK8 assays showed that knockdown Sorcin suppressed the proliferation of HCC-LM3/HuH7 cells. F, G The transwell assays accessed the effects of Sorcin knockdown on cell migration in HCC-LM3 and HuH7 cells. H, I Wound-healing assays, representative images of the HCC-LM3/HuH7 cells showed Sorcin downregulation inhibited its migration after scratching 0 h, 12 h, 24 h, and 48 h. J, K The transwell invasion assays to analyze the effect of Sorcin knockdown on the invasion ability of HCC-LM3 and HuH7 cells. Data are indicated as mean±SD; multiple comparisons were performed using one-way ANOVA; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns no significance.

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