Fig. 7: Inhibition of Caspase-1 reversed the inhibitory effect of Sorcin knockdown on the malignant progression of HCC. | Cell Death & Disease

Fig. 7: Inhibition of Caspase-1 reversed the inhibitory effect of Sorcin knockdown on the malignant progression of HCC.

From: Sorcin regulate pyroptosis by interacting with NLRP3 inflammasomes to facilitate the progression of hepatocellular carcinoma

Fig. 7

A Representative images of wound-healing assays of HCC-LM3 and HuH-7 cells showed that Caspase-1 knockdown promoted the migration of Sorcin inhibition-induced suppression cell migration at 0 h,12 h, 24 h, and 48 h. B Transwell invasion assays showed that suppression of Cspase-1 promoted cell invasion in HCC-LM3 and Huh-7 cells. C The CCK8 cell proliferation assays demonstrated Caspase-1 knockdown promoted the proliferation ability of HCC cells. D HCC-LM3 and HuH7 cells of Sorcin knockdown with shRNA interference were pre-treated with 10 μg/mL VX765 for 24 h, and then the transwell assays revealed that inhibition of Caspase-1 expression by VX765 promoted cell migration. E The transwell invasion assays revealed that Sorcin knockdown inhibited the invasion ability of HCC cells, and VX765 treatment partially restored the invasion ability. One-way ANOVA was used for multiple comparisons; *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, and ns no significance.

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