Fig. 2: Various mechanisms through which COVID-19 associated pathogenesis takes place after SARS-CoV-2 infection.
From: Immune landscape and redox imbalance during neurological disorders in COVID-19
A Cellular damage is mediated directly by the virus. B RAAS dysregulation because of ACE2 downregulation associated with the viral entry, leading to reduced cleavage of angiotensin I and angiotensin II. C Damage of endothelial cell and thrombo-inflammation; and D dysregulated immune response and hyperinflammation elicited by interferon signal inhibition by the virus, depletion of T-cell, and the generation of proinflammatory cytokines, majorly IL-6 and TNF-α (Figure prepared with Biorender).
