Fig. 1: TAMs infiltration positively correlates with CRC resistance to 5-FU. | Cell Death & Disease

Fig. 1: TAMs infiltration positively correlates with CRC resistance to 5-FU.

From: Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22–CCR4–ATF6–GRP78 axis

Fig. 1

A Immunohistochemistry was applied to detect the infiltration of TAMs (Marked with CD206) in clinical samples. B TAMs were marked with CD206 antibody, and the integrated option density (IOD) was used to quantify the positive areas of immunohistochemical staining. C Effect of M1-CM-T on the decreases of DLD1, SW480, and SW620 cell viability induced by 5-FU. D Effect of TAMs-CM-T on the decreases of DLD1, SW480, and SW620 cell viability induced by 5-FU; *p < 0.05, **p < 0.01. E Effect of TAMs-CM-H on the decreases of DLD1 and SW480 cell viability induced by 5-FU, **p < 0.01. F Effect of 20% TAMs-CM-T on the diminution of DLD1 cell colony formation capacity induced by 5-FU, **p < 0.01. G The line graph indicates the DLD1 cell colony formation capacity that was shown in panel F, **p < 0.01. H Effect of 20% TAMs-CM-T on the diminution of SW480 cell colony formation capacity induced by 5-FU, **p < 0.01. I The line graph indicated the SW480 cell colony formation capacity that was shown in H, **p < 0.01.

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