Fig. 8: GRP78 is required for M2 macrophages to promote 5-FU resistance of tumor cells in vivo. | Cell Death & Disease

Fig. 8: GRP78 is required for M2 macrophages to promote 5-FU resistance of tumor cells in vivo.

From: Tumor-associated macrophages confer colorectal cancer 5-fluorouracil resistance by promoting MRP1 membrane translocation via an intercellular CXCL17/CXCL22–CCR4–ATF6–GRP78 axis

Fig. 8

A Photographs of tumors in mice after being administered with 5-FU. The tumor was formatted with DLD1 cells, DLD1 cells + TAMs, and DLD1 (shGRP78) cells + TAMs, respectively. B The volume of tumors was measured once a week during the experiment, **p < 0.01. C Mass of dissected tumors, **p < 0.01. D Immunohistochemical staining with antibodies against GRP78 and CD206 was performed on the dissected tumors. E The photo of macroscopic colon tumors induced by AOM/DSS. F The number of macroscopic tumors (tumors larger than 1 mm in diameter), *p < 0.05. G The tumor burden of AOM/DSS induced mice, *p < 0.05. H The macroscopic findings of 5-FU sensitive and insensitive tumors. I The expression of GRP78 and the infiltration of TAMs were detected by immunohistochemical in 5-FU sensitive and insensitive tumors that showed in H.

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