Fig. 3: 20C improved behavioral performance in α-Syn A53T transgenic mice. | Cell Death & Disease

Fig. 3: 20C improved behavioral performance in α-Syn A53T transgenic mice.

From: A small molecule 20C from Gastrodia elata inhibits α-synuclein aggregation and prevents progression of Parkinson’s disease

Fig. 3

A Diagram of the experimental design. 20C (50 mg/kg) or vehicle (0.5% CMC-Na) was intragastric (i.g.) for 40 consecutive days, their motor behavioral tests were performed on day 10, 20, 30 and 40, and emotional states were tested after the last motor determination, then, tissues were harvested for follow-up analyses. B The sucrose preference in the sucrose preference test. C The latency to feed in the Novelty suppressed feeding test. Time to descend pole (D), to traverse beam apparatus (E), to fall latency from an accelerating rotarod (F) and grip strength analysis (G). H Total distance of open-field test. Error bars are represented as SEM of mean values, n = 6. *p < 0.05, **p < 0.01 vs. the control group.

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