Fig. 5: Oligoclonal and clonal expansion in TRAF2/3 double deficient B cells. | Cell Death & Disease

Fig. 5: Oligoclonal and clonal expansion in TRAF2/3 double deficient B cells.

From: TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs

Fig. 5

A Productive Simpson clonality showing the extent of clonal expansion in sequenced B cell samples (n = 5) with WT B6 spleen as control. B The top 2 expanded BCR (Igh) clonotypes are shown for each sample (n = 5), including productive frequency, the number of total productive templates (Seq#), CDR3 amino acid (a.a.), CDR3 rearrangement and V gene usage. Green color: start of CDR3 in V-gene; violet color: N1 junction; blue color: D-gene; pink color: N2 junction; yellow color: J-gene. C Pareto plots of sequencing data to show the cumulative percentage of top 20 BCR (Igh) clonotypes in each sample including WT B6 as a control. Each clonotype shown contains the same CDR3 a.a. and VDJ gene usage.

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