Fig. 1: β cell-specific Men1 knock-out mice develop non-functional PanNETs. | Cell Death & Disease

Fig. 1: β cell-specific Men1 knock-out mice develop non-functional PanNETs.

From: Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors

Fig. 1

A Pancreatic sections of 45-week-old wild-type mice and Men1f/f-RipCre+ mice fed a normal diet were stained with hematoxylin and eosin (HE). B, C Body weights (B) and blood glucose levels (C) of 45-week-old wild-type (N = 19) or Men1f/f-RipCre+ (N = 21) mice fed a normal diet. Mice were fed ad libitum. Data are represented as the mean ± standard error of the mean (SEM). D Serum insulin levels of 45-week-old wild-type (N = 19) or Men1f/f-RipCre+ mice fed a normal diet (N = 18). Mice were fed ad libitum. Data are represented as the mean ± SEM. E Pancreatic sections of 45-week-old wild-type or Men1f/f-RipCre+ mice fed a normal diet were stained with anti-insulin, anti-glucagon, and anti-Chromogranin A.

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