Fig. 6: Ketogenic diet suppresses pituitary NET development. | Cell Death & Disease

Fig. 6: Ketogenic diet suppresses pituitary NET development.

From: Metabolic intervention by low carbohydrate diet suppresses the onset and progression of neuroendocrine tumors

Fig. 6

A Pituitary sections of 45-week-old wild-type mice fed a normal diet, Men1f/f-RipCre+ mice fed a normal diet or ketogenic diet from 10 weeks of age were stained with HE. B Pituitary sizes of 45-week-old wild-type mice fed a normal diet, Men1f/f-RipCre+ mice fed a normal diet or ketogenic diet from 10 to 13 weeks of age were analyzed. Pituitaries of 10-week-old Men1f/f-RipCre+ mice fed a normal diet were also analyzed. Data are represented as the mean ± SD. C Statistical analysis of the pituitary sizes of each group of mice was performed. P values were obtained using the one-way ANOVA test. The ages of the mice sacrificed are shown in parentheses. D, E. Pituitary sections of 45-week-old wild-type mice fed a normal diet, and Men1f/f-RipCre+ mice fed a ketogenic diet from 13 weeks of age were stained with anti-prolactin (D) and anti-TSH (E) antibodies. F Pituitary sizes of 55-week-old Men1f/f-RipCre+ mice fed a normal diet or ketogenic diet from 10 to 13 weeks of age were analyzed and compared to those of 45-week-old mice. The data for the 45-week-old mice is the same as in (B). Data are represented as the mean ± SD. G Statistical analysis of the pituitary sizes of each group of mice was performed as in (C).

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