Fig. 1: Neat1 is upregulated in the PBMCs of AU patients and antigen-specific Th17 cells of EAU mice. | Cell Death & Disease

Fig. 1: Neat1 is upregulated in the PBMCs of AU patients and antigen-specific Th17 cells of EAU mice.

From: LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation

Fig. 1

A Heatmap of upregulated lncRNAs in PBMCs of AU patients compared with healthy controls. Upregulated lncRNAs were sorted via analysis of dataset GSE198533 (including 10 BD patients and 10 healthy controls) and GSE17114 (containing 15 BD patients and 14 healthy controls). B Venn diagram showing the overlap between lncRNAs upregulated in two publicly available datasets of AU patients (GSE17114 and GSE198533). C Real-time qRT-PCR analysis of Neat1 expression in CD4+ T cells from naïve (Ctrl) and EAU mice (n = 6 per group). D Kinetic expression of Neat1 expression in CD4+ T cells during the course of EAU (n = 4 per group). E–H CD4+ T cells were isolated from EAU mice and co-cultured with APCs and IRBP1-20 under indicated conditions for 48 h. Real-time qRT-PCR analysis of Neat1 expression (n = 4 per group). Data are presented as mean ± SD of at least three independent experiments. *p < 0.05, **p < 0.01.

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