Fig. 4: Silencing of Neat1 in Th17 cells ameliorates EAU. | Cell Death & Disease

Fig. 4: Silencing of Neat1 in Th17 cells ameliorates EAU.

From: LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation

Fig. 4

A Schematic diagram of EAU induced by adoptive transfer. B Clinical scores of EAU in naïve C57BL/6 mice adoptively transferred with ASO-NC (T-ASO-NC) or ASO-Neat1 (T-ASO-Neat1)-transfected Th17 cells (n = 6 per group). C Histopathological analysis of eyes from the transferred EAU mice (n = 6 per group). Scale bars, 100 μm. D Representative images of eyes in the transferred EAU mice by retinal imaging microscope. E Representative images showing fundus condition by SD-OCT. Hyper-reflective foci (blue asterisk) in the vitreous cavity and retinal folds (yellow arrows) were observed around the optical nerve. Data are representative of the analysis of three independent experiments. Error bars represent the mean ± SD. *p < 0.05, **p < 0.01.

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