Fig. 7: Schematic showing the molecular mechanisms by which Neat1 regulates antigen-specific Th17 cell responses in EAU. | Cell Death & Disease

Fig. 7: Schematic showing the molecular mechanisms by which Neat1 regulates antigen-specific Th17 cell responses in EAU.

From: LncRNA Neat1 targets NonO and miR-128-3p to promote antigen-specific Th17 cell responses and autoimmune inflammation

Fig. 7

The increased expression of Neat1 is induced by IL-23 signaling, and Neat1 in turn augments IL-23R expression by regulating NonO and miR-128-3p/NFAT5, thus forming a positive feedback loop to sustain antigen-specific Th17 cell responses that contribute to the progression of EAU.

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