Fig. 7: HDAC3 is upregulated in activated myeloid cells in vivo after retinal injury and further increased in A1 KO retinas. | Cell Death & Disease

Fig. 7: HDAC3 is upregulated in activated myeloid cells in vivo after retinal injury and further increased in A1 KO retinas.

From: The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury

Fig. 7

A–D Western blotting and analyses showed upregulation of HDAC3 but not HDAC1 and HDAC2 in the A1+/- retinas at day 2 after IR-injury. N = 3–4. *p < 0.05 vs. WT sham and WT IR, n.s. = not statistically significant, two-way ANOVA. E HDAC3 immunolabeling studies on retina sections showed baseline expression in the ganglion cell and inner nuclear layers (GCL & INL) while there was a strong co-localization with Iba-1 positive cells after retinal IR-injury. N = 3. F, G HDAC3 immunolabeling on retina flat mounts showed strong expression in Iba-1 positive cells in the ganglion cell and inner plexiform layers (GCL & IPL) after retinal IR-injury. N = 3.

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