Fig. 7: Collaborative treatment with IL-33-Ab and erastin alleviated endometriosis in a mouse model.
From: Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis
A Schematic diagram showing the mouse endometriosis model establishment and therapy process. B, C Representative photo of ectopic lesions in four groups (n = 6) at day 10. D, E Comparison of the volume (D) and weight (E) of endometriosis ectopic lesions in four groups at day 10. F Line chart for the mice weight in the four groups (n = 6) at different time points, which showed no significant change. G Hematoxylin–eosin staining (H&E staining) showing that glandular and stromal structures of endometriosis ectopic lesions in four groups (original magnification ×200). H, I Representative immunohistochemical images staining with ST2 (H) and SLC7A11 (I) in four groups endometriosis ectopic lesions.(original magnification ×200). Data are presented as the mean ± SD, n = 3 independent experiments. Statistical analysis was performed using Two-way ANOVA (D) and one-way ANOVA (E, F). ****p < 0.0001, ***p < 0.001, *p < 0.05, ns non-significant, E2 17-β-estradiol-3-benzoate, i.p. intraperitoneal injection, era erastin.
