Fig. 2: ChemR23 activation by RvE1 or C-9 improved cognitive impairment in CCH rats.

A Representative exploring traces of rats in different groups during the probe trial. B The escape latency of rats to reach the platform during the acquisition test. n = 9 per group. C The numbers of platform crossings in the probe trial. n = 9 per group. D Percentage of time spent in the 3rd quadrant of rats in the probe trial. n = 9 per group. E Average swimming speeds of rats in different groups during the probe trial. n = 9 per group. Data are presented as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. sham; #P < 0.05, ##P < 0.01, ###P < 0.001 vs. CCH; N.S. means not significant.