Fig. 5: ChemR23 activation with RvE1 or C-9 regulated PI3K/AKT/Nrf2 signalling pathway in CCH rats. | Cell Death & Disease

Fig. 5: ChemR23 activation with RvE1 or C-9 regulated PI3K/AKT/Nrf2 signalling pathway in CCH rats.

From: ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis

Fig. 5

A Volcano plots of DEGs of the RvE1 group vs. the CCH group and the C-9 group vs. the CCH group. n = 3 per group. B Total numbers of upregulated or downregulated genes in the RvE1 group vs. the CCH group and the C-9 group vs. the CCH group. n = 3 per group. C A Venn diagram displaying the intersection of DEGs for RvE1 vs. CCH and C-9 vs. CCH. n = 3 per group. D The intersection of DEGs for RvE1 vs. CCH and C-9 vs. CCH was analysed by KEGG enrichment and the top 5 enriched pathways are shown. n = 3 per group. E–H Representative immunoblotting bands and the levels of p-PI3K/PI3K, p-AKT/AKT and Nrf2 in the rat hippocampus. n = 4 per group. Data are presented as the mean ± SEM. **P < 0.01, ***P < 0.001 vs. sham; #P < 0.05 vs. CCH.

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