Fig. 5: CircHECTD1-463aa inhibited the proliferation, migration, invasion, and VM formation in GBM cells. | Cell Death & Disease

Fig. 5: CircHECTD1-463aa inhibited the proliferation, migration, invasion, and VM formation in GBM cells.

From: RBMS3-induced circHECTD1 encoded a novel protein to suppress the vasculogenic mimicry formation in glioblastoma multiforme

Fig. 5

A Relative expression of 463aa in NBT (n = 3), LGGT (n = 9), and GBM (n = 9) was shown by western blot; *P < 0.05, **P < 0.01 vs NBT group; ##P < 0.01 vs LGGT group. B The expression level of 463aa in NHA, U87, and U251 cells (n = 3). **P < 0.01 vs NHA group. C Subcellular distribution of 463aa in U87 and U251 cells shown by IF assay. Scale bar = 10 μm. D–G 463aa inhibited cell proliferation, migration, invasion, and VM-channel formation of U87 and U251 cells. Scale bar = 200 μm. H Overexpression of 463aa decreased the expression level of VM-related protein shown by western blot (n = 3). *P < 0.05, **P < 0.01 vs OV-NC group. I The sequence analysis of the 463aa domain from the NCBI database.

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