Fig. 8: Identification and analysis of the hub transcriptional factors (TFs). | Cell Death & Disease

Fig. 8: Identification and analysis of the hub transcriptional factors (TFs).

From: Identification of multiple organ metastasis-associated hub mRNA/miRNA signatures in non-small cell lung cancer

Fig. 8

A Hub TFs were selected based on overlap between the 123 candidate hub genes and 314 TFs. B, D, F RB1, TP63 and PRDM1 expression in NSCLC distant metastasis tissues, primary and adjacent tumor tissues based on the TCGA NSCLC cohort. C, E, G RB1, TP63 and PRDM1 expression in NSCLC tissues with or without lymph metastasis based on GSE30219 dataset. H–K mRNA expression of key TFs in BoM, BrM, LnM and LuM cell lines relative to L9981. L, M Depict of potential TFs regulating miR-660-5p transcription as well as transcriptional targets of TP63 and RB1 based on public databases.

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