Fig. 3: Analysing contractile responses in vascular rings from Brn-3b KO aortas. | Cell Death & Disease

Fig. 3: Analysing contractile responses in vascular rings from Brn-3b KO aortas.

From: Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways

Fig. 3

Echocardiography data showing changes in ascending aortic velocity (a) and measurement of aortic root diameter in male Brn-3b KO mice (b), when compared with age-matched WT controls. c Graph showing IC100 measurement (from wire myography) to measure differences in elastic properties of vascular rings from WT and Brn-3b KO mice at baseline. d Summary of data showing responses of thoracic aortic vascular rings from Brn-3b KO aortas and WT controls, following treatment with cumulative concentration of (i) KCl, (ii) PE and (iii) PGH2 prostaglandin analogue, u46619. Graphs show changes in force of contraction (DmN) elicited following different treatments, as shown. Data represents mean and standard error of measurements from vascular rings taken from 6 independent Brn-3b KO and WT aortas. Statistical significance was determined using two-way ANOVA analysis.

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