Fig. 5: Summary of data obtained from DEG2 analysis differentially expressed genes in Brn-3b KO aortas when compared with WT controls. | Cell Death & Disease

Fig. 5: Summary of data obtained from DEG2 analysis differentially expressed genes in Brn-3b KO aortas when compared with WT controls.

From: Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways

Fig. 5

a Heat map showing differential expression of genes (DEG) in Brn-3b KO aortas, compared with WT controls- down-regulated = top panel; up-regulated = bottom panel. b VENN diagram showing the numbers of up and down-regulated genes, using FDR cut-off = 0.1; fold change =1.5 c Schematic diagram showing how genes that are up-regulated or down-regulated in Brn-3b KO aortas are linked in the calcium signalling pathway. Modified KEGG Image was rendered by Pathview with red boxes indicating genes that were increased in Brn-3b KO aortas while green boxes indicate decreased genes and grey indicate unchanged expression.

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