Fig. 8: Proposed mechanism by which gene expression changes caused by loss of Brn-3b may affect VSMC fate and function and thereby vascular contractility. | Cell Death & Disease

Fig. 8: Proposed mechanism by which gene expression changes caused by loss of Brn-3b may affect VSMC fate and function and thereby vascular contractility.

From: Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways

Fig. 8

a Schematic diagram of Ca2+ regulation of contraction and S/ER stress responses in normal contractile VSMC. b Effects caused by loss of Brn-3b which caused changes in selected genes that regulate Ca2+ signalling or stress responses in Brn-3b KO VSMC. Genes up-regulated in Brn-3b KO cells are shown in red and down-regulated genes in blue. ‘X’ indicates inhibition of function or loss of expression. Image created in by Biorender.

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