Table 2 Selected genes that were differentially regulated in Brn-3b KO aortas.

From: Vascular dysfunction caused by loss of Brn-3b/POU4F2 transcription factor in aortic vascular smooth muscle cells is linked to deregulation of calcium signalling pathways

a) Selected Genes increased in male Brn-3bKO aorta
Symbol	KO-WT log2 Fold Change	ENSEMBL	Description
*Calcium regulation*
Ryr2	1.79	ENSMUSG00000021313	ryanodine receptor 2, cardiac
Cacna2d2	1.41	ENSMUSG00000010066	calcium channel, voltage-dependent, alpha 2/delta subunit 2
Cacna1h	1.83	ENSMUSG00000024112	calcium channel, voltage-dependent, T type, alpha 1H subunit
Cacna1d	1.04	ENSMUSG00000015968	calcium channel, voltage-dependent, L type, alpha 1D subunit
Pln	0.95	ENSMUSG00000038583	phospholamban
Camk1g	0.94	ENSMUSG00000016179	calcium/calmodulin-dependent protein kinase I gamma
*Muscle (Sarcomeric or regulatory proteins)*
Pla2g2e	1.55	ENSMUSG00000028751	phospholipase A2, group IIE
Tcap	1.87	ENSMUSG00000007877	titin-cap
Nppa	1.78	ENSMUSG00000041616	natriuretic peptide type A
Mmp12	1.62	ENSMUSG00000049723	matrix metallopeptidase 12
*Other*
Ciart	4.67	ENSMUSG00000038550	circadian associated repressor of transcription
Dbp	4.18	ENSMUSG00000059824	D site albumin promoter binding protein
Gpr22	3.13	ENSMUSG00000044067	G protein-coupled receptor 22
Alox8	2.47	ENSMUSG00000020891	arachidonate 8-lipoxygenase
Nr1d2	2.43	ENSMUSG00000021775	nuclear receptor subfamily 1, group D, member 2
Thsd7b	2.22	ENSMUSG00000042581	thrombospondin, type I, domain containing 7B
Hcn1	2.15	ENSMUSG00000021730	hyperpolarization activated cyclic nucleotide gated potassium channel 1
Nr1d1	1.75	ENSMUSG00000020889	nuclear receptor subfamily 1, group D, member 1
Cyp2f2	1.78	ENSMUSG00000052974	cytochrome P450, family 2, subfamily f, polypeptide 2
Per2	1.69	ENSMUSG00000055866	period circadian clock 2
Hamp	1.67	ENSMUSG00000050440	hepcidin antimicrobial peptide
Gpr158	1.66	ENSMUSG00000045967	G protein-coupled receptor 158
Kcp	1.56	ENSMUSG00000059022	kielin/chordin-like protein [
Slc16a12	1.56	ENSMUSG00000009378	solute carrier family 16 (monocarboxylic acid transporters), member 12
Zfp791	1.54	ENSMUSG00000074194	zinc finger protein 791
Wdfy1	1.44	ENSMUSG00000073643	WD repeat and FYVE domain containing 1

b) Selected genes down-regulated in male Brn-3b KO aorta
*Calcium regulation*
Atp2a1	−2.57	ENSMUSG00000030730	ATPase, Ca++ transporting, cardiac muscle, fast twitch 1
Tnni2	−2.38	ENSMUSG00000031097	troponin I, skeletal, fast 2
S100a9	−2.28	ENSMUSG00000056071	S100 calcium binding protein A9 (calgranulin B)
Ryr1	−2.19	ENSMUSG00000030592	ryanodine receptor 1, skeletal muscle
S100a8	−2.09	ENSMUSG00000056054	S100 calcium binding protein A8 (calgranulin A)
Trpm2	−1.38	ENSMUSG00000009292	transient receptor potential cation channel, subfamily M, member 2
Casq1	−0.95	ENSMUSG00000007122	calsequestrin 1
Orai2	−0.65	ENSMUSG00000039747	ORAI calcium release-activated calcium modulator 2
*Muscle (Sarcomeric or regulatory proteins)*
Actn3	−2.64	ENSMUSG00000006457	actinin alpha 3
Mybpc2	−2.65	ENSMUSG00000038670	myosin binding protein C, fast-type
Mylpf	−2.58	ENSMUSG00000030672	myosin light chain, phosphorylatable,
Myh1	−2.18	ENSMUSG00000056328	myosin, heavy polypeptide 1, skeletal muscle,
Myl3	−1.90	ENSMUSG00000059741	myosin, light polypeptide 3
Eln	−1.86	ENSMUSG00000029675	elastin
Mmp8	−1.47	ENSMUSG00000005800	matrix metallopeptidase
Foxs1	−1.69	ENSMUSG00000074676	forkhead box S1
Ckm	−1.06	ENSMUSG00000030399	creatine kinase, muscle
Mylk2	−1.04	ENSMUSG00000027470	myosin, light polypeptide kinase 2
Lox	−1.08	ENSMUSG00000024529	lysyl oxidase
Gpr20	−1.01	ENSMUSG00000045281	G protein-coupled receptor 20
Npr1	−0.98	ENSMUSG00000027931	natriuretic peptide receptor 1
Mmp3	−0.94	ENSMUSG00000043613	matrix metallopeptidase 3
Adamts15	−0.94	ENSMUSG00000033453	disintegrin-like &metallopeptidase thrombospondin type 1 motif, 15
Angptl4	−0.88	ENSMUSG00000002289	angiopoietin-like 4
Mmp9	−0.88	ENSMUSG00000017737	matrix metallopeptidase 9
*Immune*
Cxcr2	−2.99	ENSMUSG00000026180	chemokine (C-X-C motif) receptor 2
Serpina3k	−2.78	ENSMUSG00000058207	serine (or cysteine) peptidase inhibitor, clade A, member 3K
Il1b	−2.38	ENSMUSG00000027398	interleukin 1 beta
Ccl12	−1.54	ENSMUSG00000035352	chemokine (C-C motif) ligand 12
Nfil3	−1.46	ENSMUSG00000056749	nuclear factor, interleukin 3, regulated
Trim10	−1.39	ENSMUSG00000073400	tripartite motif-containing 10
Csf3r	−1.68	ENSMUSG00000028859	colony stimulating factor 3 receptor (granulocyte)
Igsf9	−1.25	ENSMUSG00000037995	immunoglobulin superfamily, member 9
*Others*
Arntl	−2.51	ENSMUSG00000055116	aryl hydrocarbon receptor nuclear translocator-like
Cyp1a1	−1.71	ENSMUSG00000032315	cytochrome P450, family 1, subfamily a, polypeptide 1
Rnf150	−1.67	ENSMUSG00000047747	ring finger protein 150
Dhrs9	−1.44	ENSMUSG00000027068	dehydrogenase/reductase (SDR family) member 9
Cdkn1a	−1.43	ENSMUSG00000023067	cyclin-dependent kinase inhibitor 1A (P21)
Slc25a34	−1.37	ENSMUSG00000040740	solute carrier family 25, member 34
Padi4	−1.18	ENSMUSG00000025330	peptidyl arginine deiminase, type IV
Retn	−0.67	ENSMUSG00000012705	resistin

a) Selected upregulated genes that in male Brn-3b KO aortas are grouped according to key known function; log-2-fold change [with (+) indicating upregulation and (−) downregulation]; ENSEMBL ID and brief description of each gene.
b) List of selected genes that were down-regulated in male Brn-3b KO aortas.

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Table 2 Selected genes that were differentially regulated in Brn-3b KO aortas.

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