Fig. 1: Differential expression of pyroptosis-associated markers and macrophage subpopulations in decidual tissues between patients with URSA and control patients. | Cell Death & Disease

Fig. 1: Differential expression of pyroptosis-associated markers and macrophage subpopulations in decidual tissues between patients with URSA and control patients.

From: Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface

Fig. 1

A Differences in the protein expression levels of GSDMD, GSDMD-N, pro-caspase-1 and mature caspase-1 in decidual tissues between patients in the URSA group and the control group. B FCM analysis shows the content of CD14-labeled macrophages, FVS-labeled live/dead cells, and the contents of M1 macrophages labeled by CD86 and M2 macrophages labeled in CD209 in viable and dead cells in the decidual tissues in one patient with URSA and one control patient. a shows that the percentages of all the macrophages with CD14 (+) in the URSA and control groups are 5.02% and 1.32%, respectively; b shows that the percentages of CD14 (+) in FVS (−) and FVS (+) in the URSA and control groups are 53.6%, 42.1%, 28.4% and 38.2%; C shows that the percentages of macrophages showing the FVS (−) survival status represented by CD86 (+) M1 macrophages in the URSA group and control group are 38.5% and 33.3%, respectively; d shows that the percentages of macrophages showing the FVS (−) survival status represented by CD209 ( + ) M2 macrophages in the URSA and control groups are 31.2% and 71.5%, respectively; e shows that the percentages of macrophages showing the FVS (+) dead status represented by CD86 (+) M1 macrophages in the URSA group and control group are 45.4% and 30.4%; f shows that the percentages of macrophages showing the FVS (+) dead status represented by CD209 (+) M2 macrophages in the URSA group and control group are 22.5% and 55.2%. C FCM analysis of differences in total macrophage content in decidual tissues between patients in the URSA group and the control group. D FCM analysis of the proportion of macrophage survival and death in the uterine decidual tissues of patients in the URSA group and the control group. E FCM analysis of the difference in the proportion of M1 and M2 macrophages in the surviving and dead macrophages of the URSA group and the control group. *P < 0.05, **P < 0.01, ns = nonsignificant.

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