Fig. 10: Pattern diagram. | Cell Death & Disease

Fig. 10: Pattern diagram.

From: Investigation into the role of the MITA-TRIM38 interaction in regulating pyroptosis and maintaining immune tolerance at the maternal-fetal interface

Fig. 10

In macrophages at the maternal-fetal interface, when M1 macrophages were dominant, the high expression of MITA promoted the conversion of GSDMD to GSDMD-N, thus promoting pyroptosis, manifested as a proinflammatory effect, which led to URSA. When M2 macrophages were dominant, MITA mediated by TRIM38 led to low expression, which suppressed pyroptosis, manifested by an anti-inflammatory effect and subsequent maintenance of normal pregnancy (N.P.). However, when pyroptosis was inhibited by VX765, it could cause the conversion of M1 to M2 macrophages.

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