Fig. 6: Improved metabolic fitness in ML323 treated HFD-induced obese mice. | Cell Death & Disease

Fig. 6: Improved metabolic fitness in ML323 treated HFD-induced obese mice.

From: Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulation

Fig. 6

All mouse phenotypes were characterized 16 weeks after being fed a NFD or a HFD. A, B Body weight of mice treated with vehicle or ML323, fed an NFD or a HFD for 16 weeks with ML323 treatment starting on week 8. C Weight of gWAT and iWAT from vehicle-treated and ML323-treated mice. D Food intake of vehicle-treated and ML323-treated mice. E Metabolic parameters of vehicle-treated and ML323-treated mice. The metabolic parameters were measured for 1 week using a metabolic cage. F Serum concentrations of AST, ALT, cholesterol, triglyceride, and free fatty acid from vehicle-treated and ML323-treated mice. Data represent the mean ± SEM (n = 5 for each group) *p < 0.05, **p < 0.01, and ***p < 0.001 for vehicle-treated vs. ML323-treated mice. Statistical significance was determined by two-tailed unpaired t test.

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