Fig. 1: HI contributes to neuronal impairment and augmentation of hippocampal global methylation. | Cell Death & Disease

Fig. 1: HI contributes to neuronal impairment and augmentation of hippocampal global methylation.

From: N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

Fig. 1

Neonatal rats were treated with HI exposure at PND7. A, B TTC staining was used to quantify cerebral infarct volumes in rats from different groups 48 h post-HI. C Nissl staining was used to assess relative changes and examine neuronal cell death in hippocampal neurons (scale bar = 100/200 µm). D, E Hippocampal m6A levels were analyzed by dot blot. m6A quantification is shown in the right panel. F, G Immunofluorescence was conducted to evaluate m6A in sham and HI samples (scale bar = 50 µm). Data are presented as means ± standard deviations. *p < 0.05 vs. the Sham group; #p < 0.05 vs. the Contral group.

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