Fig. 3: Conjoint analysis of hippocampal RNA-seq and methylated RNA immunoprecipitation sequencing 2 days post-HI. | Cell Death & Disease

Fig. 3: Conjoint analysis of hippocampal RNA-seq and methylated RNA immunoprecipitation sequencing 2 days post-HI.

From: N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

Fig. 3

A Cluster heat map shows differentially expressed RNA between the sham and HI treatment groups (n = 3). B–E GO and KEGG analysis were performed using genes that were significantly differentially expressed in the HI treatment group (Edge R P ≤ 0.05). Significantly enriched biological processes (BP), molecular function (MF) and cellular component (CC) are depicted in the RNA-seq graph. F Cluster heat map shows differentially methylated RNA between the sham and HI treatment groups (n = 3). G–J GO and KEGG analysis were performed using genes that were significantly differentially methylated in the HI treatment group (Edge R P ≤ 0.05). K Venn diagrams of aberrantly methylated differentially expressed genes. L Four quadrant graph showing the distribution of transcripts with significant changes in both m6A-modified level and corresponding mRNA expression 48 h post-HI.

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