Fig. 4: Activation of AKT pathway and augment of autophagic flux induced by HI treatment. | Cell Death & Disease

Fig. 4: Activation of AKT pathway and augment of autophagic flux induced by HI treatment.

From: N6-methyladenosine demethylase FTO regulates synaptic and cognitive impairment by destabilizing PTEN mRNA in hypoxic-ischemic neonatal rats

Fig. 4

A–D Western blot analysis of expression of PTEN and AKT, mTOR phosphorylation among sham, contralateral and ipsilateral hippocampus samples at 48 h after HI exposure. E–H Western blot analysis for LC3II and p62, Beclin1 after HI exposure in neonatal rats. The blots shown are representative of at least 4 experiments with similar results. Data are presented as means ± standard deviations. *p < 0.05 vs. the Sham group; #p < 0.05 vs. the Contral group.

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