Fig. 1: Malignant melanoma comprises about 20% p53 mutations.
From: A cytosolic mutp53(E285K) variant confers chemoresistance of malignant melanoma
A The frequency of p53 mutations taken from https://www.cbioportal.org was multiplied by the case number of the selected cancers https://gco.iarc.fr/today to get the estimated cases of mutant p53. B Percentage of different p53 alterations in melanoma analyzed from https://www.cbioportal.org/study/summary?id=msk_met_2021. C Full atom p53 structure with positions of mutations. NTD (1-93) = Intrinsically Disordered N-terminal Domain (gray); CTD (360-393) = C-terminal domain (brown); NES (340–351) = nuclear localization signal (yellow); TET (323–360) = tetramerization domain (purple); DBD (94–294) = DNA-binding domain (light blue). Spheres indicate the positions of missense mutations observed in tumor samples according to https://tp53.isb-cgc.org. The radii of spheres correspond to the mutation frequency in cancer.
