Fig. 2: Rnf115 knockout decreases hepatic inflammation in ALI mice induced by LPS/D-GaIN. | Cell Death & Disease

Fig. 2: Rnf115 knockout decreases hepatic inflammation in ALI mice induced by LPS/D-GaIN.

From: RNF115/BCA2 deficiency alleviated acute liver injury in mice by promoting autophagy and inhibiting inflammatory response

Fig. 2

a The levels of TNF, IL-6, and MCP1/CCL2 in serum with different mice were detected by LEGENDplex™ mouse proinflammatory chemokine panel. b The levels of Tnf, Il-6, Mcp1/Ccl2, Il-1β and Ifnβ1 mRNA in the livers of different mice were measured by qRT–PCR. c The levels of MPO in the livers of different mice were detected. d The percentage of CD11b+CD14+ monocytes and CD11b+Ly6G+ neutrophils in livers were analyzed by Flow cytometry. e Ly6G+ cells were detected by immunohistochemical analysis. Isotype IgG staining was used as a negative control. *p < 0.05, **p < 0.01, ns: no significance.

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