Fig. 2: GSDME converts caspase-3-dependent apoptosis into pyroptosis. | Cell Death & Disease

Fig. 2: GSDME converts caspase-3-dependent apoptosis into pyroptosis.

From: The multifaceted roles of GSDME-mediated pyroptosis in cancer: therapeutic strategies and persisting obstacles

Fig. 2

a The intrinsic apoptotic pathways. b The extrinsic apoptotic pathways. c The caspase-3/GSDME-mediated pyroptotic pathway. d GSDME-NT targets mitochondrial membranes to generate holes, causing the release of cytochrome c and mitochondrial DNA. GSDME works as a ‘transducer’ to determine whether a cell undergoes pyroptosis or apoptosis. Activated caspase-3 could cleave GSDME and induce pyroptotic cell death following the successful induction of apoptosis by caspase-3. Besides that, GSDME-NT cleaves the membrane of mitochondrial, which further triggers self-amplification of pyroptosis.

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