Fig. 4: CYLD induces DNA damage through HDAC1/2. | Cell Death & Disease

Fig. 4: CYLD induces DNA damage through HDAC1/2.

From: CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Fig. 4

a–c Analysis of γH2AX foci at different times after 4 Gy radiation. Immunofluorescence staining for γ-H2AX followed by confocal microscopy was performed. Cells displaying 10 or more foci were counted as positive. Representative images of γH2AX foci and the percentage of HK1-EBV and HONE1-EBV cells displaying γH2AX foci are shown. d, e Immunofluorescence staining of γH2AX followed by confocal microscopy was performed. HONE1 cells by CYLD knockdown with or without Chidamide (0.5 μM) treatment for 24 h. f Detection of γH2AX protein level in NPC cells by CYLD overexpression with or without iTSA-1 (10 μM) for 24 h treatment.

Back to article page