Fig. 6: CYLD mediates radiation sensitivity through class I HDACs. | Cell Death & Disease

Fig. 6: CYLD mediates radiation sensitivity through class I HDACs.

From: CYLD induces high oxidative stress and DNA damage through class I HDACs to promote radiosensitivity in nasopharyngeal carcinoma

Fig. 6

a, b Colony formation assay showing survival fractions of CYLD overexpressing cells (CYLD wt: full-length CYLD plasmid; CYLD △N: N-terminal deletion CYLD plasmid) treated with irradiation or untreated; surviving fractions were calculated by comparing the colony number of each treatment group with untreated groups (0 Gy). c Colony formation assay showing survival fractions of CYLD overexpressing cells treated with iTSA (10 μM) or untreated at 24 h before irradiation; surviving fractions were calculated by comparing the colony number of each treatment group with untreated groups (0 Gy). d Colony formation assay showing survival fractions of CYLD knockdown cells, CHI (Chidamide: 0.5 μM) were treated 24 h before irradiation; surviving fractions were calculated by comparing the colony number of each treatment group with untreated groups (0 Gy). Results are plotted as the mean surviving fraction ± SEM of 3 independent experiments.

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